Fumio Sakane Selected Research

Diacylglycerol Kinase

4/2022	Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade.
1/2022	Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance.
1/2022	Diacylglycerol kinase η regulates cell proliferation and its levels are elevated by glucocorticoids in undifferentiated neuroblastoma cells.
10/2021	The Roles of Diacylglycerol Kinase α in Cancer Cell Proliferation and Apoptosis.
1/2021	Combined inhibition/silencing of diacylglycerol kinase α and ζ simultaneously and synergistically enhances interleukin-2 production in T cells and induces cell death of melanoma cells.
1/2020	Palmitic acid- and/or palmitoleic acid-containing phosphatidic acids are generated by diacylglycerol kinase α in starved Jurkat T cells.
1/2020	Diacylglycerol kinase δ destabilizes serotonin transporter protein through the ubiquitin-proteasome system.
11/2019	Analytical Method for Diacylglycerol Kinase ζ Activity in Cells Using Protein Myristoylation and Liquid Chromatography-Tandem Mass Spectrometry.
11/2019	Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids.
9/2019	Microarray analysis of gene expression in the diacylglycerol kinase η knockout mouse brain.

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Fumio Sakane Research Topics

Disease

21	Neoplasms (Cancer) 04/2022 - 09/2002
9	Type 2 Diabetes Mellitus (MODY) 01/2021 - 02/2008
6	Bipolar Disorder (Manic Depressive Psychosis) 01/2022 - 11/2012
6	Melanoma (Melanoma, Malignant) 10/2021 - 04/2007
5	Hepatocellular Carcinoma (Hepatoma) 04/2022 - 07/2012
5	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/2021 - 01/2018
4	Carcinogenesis 04/2022 - 07/2007
4	Hyperglycemia 01/2022 - 11/2007
4	Mania (Manias) 01/2021 - 01/2016
4	Starvation 01/2020 - 02/2012
3	Insulin Resistance 01/2022 - 11/2007
3	Neuroblastoma 01/2022 - 01/2013
3	Parkinson Disease (Parkinson's Disease) 10/2021 - 01/2017
2	Glioblastoma (Glioblastoma Multiforme) 10/2021 - 01/2019
2	Schizophrenia (Dementia Praecox) 01/2020 - 01/2020
2	Autistic Disorder (Autism) 01/2020 - 01/2020
2	Obesity 10/2017 - 02/2008
2	Cardiomegaly (Heart Hypertrophy) 01/2016 - 08/2008
2	Epilepsy (Aura) 01/2016 - 08/2008
2	Hypertension (High Blood Pressure) 01/2016 - 08/2008
1	Liver Neoplasms (Liver Cancer) 04/2022
1	Fragile X Syndrome (Martin Bell Syndrome) 09/2020
1	Major Depressive Disorder (Major Depressive Disorders) 09/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2019
1	Adenocarcinoma 01/2019
1	Body Weight (Weight, Body) 10/2017
1	Inflammation (Inflammations) 01/2017
1	Atherosclerosis 01/2017
1	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2017
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 03/2016
1	Hypospadias 11/2012
1	Seizures (Absence Seizure) 11/2012
1	Leukemia 05/2003

Drug/Important Bio-Agent (IBA)

26	Diacylglycerol KinaseIBA 04/2022 - 09/2002
12	IsoenzymesIBA 01/2022 - 07/2007
7	Glucose (Dextrose)FDA LinkGeneric 11/2019 - 11/2007
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2003
4	Phosphotransferases (Kinase)IBA 01/2021 - 04/2007
4	EnzymesIBA 11/2019 - 02/2012
3	Carrier Proteins (Binding Protein)IBA 10/2021 - 01/2018
3	Interleukin-2 (IL2)IBA 01/2021 - 03/2016
3	DiglyceridesIBA 01/2021 - 02/2008
3	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 09/2020 - 01/2020
3	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 01/2018
3	Pharmaceutical PreparationsIBA 03/2016 - 08/2008
2	Monounsaturated Fatty AcidsIBA 01/2021 - 11/2019
2	Epidermal Growth Factor (EGF)IBA 01/2021 - 11/2002
2	Protein Isoforms (Isoforms)IBA 01/2021 - 04/2007
2	Caspase 3 (Caspase-3)IBA 01/2021 - 01/2019
2	Palmitic Acid (Hexadecanoic Acid)IBA 01/2020 - 10/2017
2	Phosphatidic Acids (Phosphatidic Acid)IBA 11/2019 - 01/2017
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2019 - 10/2017
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2018 - 12/2016
2	SynucleinsIBA 01/2018 - 01/2017
2	Insulin (Novolin)FDA Link 10/2017 - 02/2008
2	LithiumIBA 01/2016 - 01/2016
2	Messenger RNA (mRNA)IBA 01/2013 - 05/2003
2	Phorbol EstersIBA 11/2002 - 09/2002
1	LigandsIBA 04/2022
1	InterferonsIBA 04/2022
1	CytokinesIBA 04/2022
1	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 01/2022
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2022
1	Hormones (Hormone)IBA 01/2022
1	GlucocorticoidsIBA 01/2022
1	Caspase 9IBA 01/2022
1	PKC-3 proteinIBA 10/2021
1	Sirolimus (Rapamycin)FDA Link 10/2021
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 10/2021
1	Phosphates (Orthophosphate)IBA 10/2021
1	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2021
1	synaptojaninIBA 10/2021
1	ClathrinIBA 10/2021
1	Streptozocin (Streptozotocin)FDA Link 01/2021
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 10/2020
1	Lactate Dehydrogenase 5IBA 10/2020
1	Pyruvic Acid (Pyruvate)IBA 10/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 10/2020
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 09/2020
1	palmitoleic acidIBA 01/2020
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 11/2019
1	Blood Glucose (Blood Sugar)IBA 10/2017
1	Myristic Acid (Tetradecanoic Acid)IBA 10/2017
1	phosphatidylcholine-specific phospholipase CIBA 01/2017
1	dipalmitoylphosphatidic acidIBA 12/2016
1	Guanosine Triphosphate (GTP)IBA 01/2008
1	beta-chimaerinIBA 09/2007
1	NF-kappa B (NF-kB)IBA 04/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2007

Therapy/Procedure

4	Therapeutics 04/2022 - 01/2020
4	Immunotherapy 01/2022 - 01/2018
1	Oral Administration 10/2017